121 Sands Building
DUMC Box 3870
Duke University Medical Ctr.
Durham, NC 27710
Email: tong DOT lee AT duke DOT edu
Psychiatry & Behavioral Sciences, School of Medicine
The focus of our research is to elucidate neurobiological alterations that may underlie chronic psychostimulant abuse in humans. These preclinical findings, in turn, are used to develop targeted strategies for the treatment of chronic psychostimulant abusers. The current research strategies being pursued include (“bottom-up) screening and optimization of small molecule libraries and (“top-down) dosing regimen-dependent delivery of clinically-available drugs in clinical trials.
M.D., Stanford University, 1988
Ph.D., Duke University, Pharmacology, 1986
B.S., University of California, Los Angeles, Psychobiology, 1980
Yuan L, Seo J, Kang S, Keinan S, Steele S, Michelotti GM, Wetsel WC., Beratan DN, Gong YD, Lee TH, Hong J, Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse. Mol. Biosyst. 5: 927-930, 2009.
Chen Q, Zhu X, Zhang Y, Wetsel WC, Lee TH, Zhang X. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. J. Mol. Neurosci. DOI: 10.1007/s12031-009-9218-3.
Nah, S-Y, Bhatia, K, Lyles, J, Ellinwood, EH, Lee, TH. Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens. Brain Res., 1248:184-190, 2008.
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