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Tong Lee, M.D., Ph.D.

Photo of Tong Lee

Phone: 919-684-4374

121 Sands Building
DUMC Box 3870
Duke University Medical Ctr.
Durham, NC 27710

Email: tong DOT lee AT duke DOT edu

Associate Professor

Psychiatry & Behavioral Sciences, School of Medicine

DIBS Faculty

Research Description

The focus of our research is to elucidate neurobiological alterations that may underlie chronic psychostimulant abuse in humans. These preclinical findings, in turn, are used to develop targeted strategies for the treatment of chronic psychostimulant abusers. The current research strategies being pursued include (“bottom-up) screening and optimization of small molecule libraries and (“top-down) dosing regimen-dependent delivery of clinically-available drugs in clinical trials.

Education

M.D., Stanford University, 1988

Ph.D., Duke University, Pharmacology, 1986

B.S., University of California, Los Angeles, Psychobiology, 1980

Recent Publications

Yuan L, Seo J, Kang S, Keinan S, Steele S, Michelotti GM, Wetsel WC., Beratan DN, Gong YD, Lee TH, Hong J, Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse. Mol. Biosyst. 5: 927-930, 2009.

Chen Q, Zhu X, Zhang Y, Wetsel WC, Lee TH, Zhang X. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. J. Mol. Neurosci. DOI: 10.1007/s12031-009-9218-3.

Nah, S-Y, Bhatia, K, Lyles, J, Ellinwood, EH, Lee, TH. Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens. Brain Res., 1248:184-190, 2008.

Research Areas

Research Topics

  • Psychostimulant abuse
  • Translational clinical trials
  • Novel treatment development