Bryan Research Building 201E
Durham, NC 27710
Email: nicole DOT calakos AT duke DOT edu
Center for Translational Neuroscience
Neurology, School of Medicine
My laboratory studies the molecular basis and functional significance of synaptic plasticity. Particular areas of emphasis include (1) mechanisms and function of corticostriatal synaptic plasticity, (2) mechanism and function of presynaptic plasticity, and (3) role of synaptic plasticity in neurological/psychiatric disorders (i.e. dystonia, Tourette's, OCD, dementia).
Neurology residency, University of California, San Francisco, 2000
Ph.D., Stanford University, 1996
M.D., Stanford University, 1996
A.B., University of California, Berkeley, 1988
Chen, M., Wan, Y., Ade, K., Ting, J., Feng, G., and N. Calakos. Sapap3 deletion causes anomalous endocannabinoid-mediated synaptic plasticity by enhancing group 1 metabotropic glutamate receptor activity. 2011. The Journal of Neuroscience, 31(26):9563-73.
Ade, K., Wan, Y., Chen, M., Gloss, B. and N. Calakos. An improved BAC transgenic fluorescent reorter line for sensitive and specific identification of striatonigral medium spiny neurons. 2011. Frontiers in Neuroscience 5 (32):1-9.
Yang, Y. and N. Calakos. Munc13 is required for presynaptic long-term potentiation. 2011. The Journal of Neuroscience, 31(33):12053-7.
Yang, Y. and N. Calakos. Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1a serine 413 is not required for mossy fiber LTP. 2010. The Journal of Neuroscience, 30(7):2542-6, PMCID2947440.
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