Christine Marx, M.D., M.A.

Photo of Christine Marx

Phone: (919) 286-0411 Ext 7426

Durham Veterans Affairs Medical Center
508 Fulton Street
Mental Health Service Line (116A)
Durham, NC 27705

Email: marx0001 AT mc DOT duke DOT edu

Associate Professor

MIRECC (VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center)

Psychiatry & Behavioral Sciences, School of Medicine

DIBS Faculty

Research Description

We focus on neurosteroids and their relevance to the neurobiology and therapeutics of psychiatric and neurological disorders - including schizophrenia, PTSD, traumatic brain injury, smoking cessation, and Alzheimer's disease. Our laboratory quantifies these molecules in rodent and human tissues utilizing mass spectrometry-based methodologies. Investigations range from studies in rodent models of PTSD to proof-of-concept randomized controlled trials investigating neurosteroids as pharmacological interventions. We also have an interest in neurosteroids as candidate biomarkers for CNS disorders and the prediction of therapeutic response.


NIMH Fellowship, University of North Carolina, Chapel Hill (Clinical and Applied Neuroscience), 1997-1999

Psychiatry Residency, Duke University School of Medicine, 1994-1997

M.D., Duke University School of Medicine, 1993

M.A., University of Virginia (German Literature), 1988

B.A., Swarthmore College (German Literature), 1986

Recent Publications

Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD. Pregnenolone as a Novel Candidate Therapeutic in Schizophrenia: Emerging Preclinical and Clinical Evidence. In Press, Neuroscience.

Hayes JP, LaBar KS, McCarthy G, Selgrade E, Nasser J, Dolcos F, VISN6 Mid-Atlantic MIRECC Workgroup [Beckham JC, Calhoun PS, Davison RM, Eggleston AM, Fairbank JA, Green KT, Kirby AC, Hoerle JM, Marx CE, Moore SD, Payne V, Pender MC, Petty C, Strauss FL, Straits-Troster KA, Weiner RD], Morey RA. Reduced Hippocampal and Amygdala Activity Predicts Memory Distortions for Trauma Reminders in Combat-Related PTSD. Journal of Psychiatric Research 2011; 45:660-669.

Strauss JL, Marx CE, Weitlauf JC, Stechuchak KM; Straits-Tröster K, Worjoloh AW, Sherrod CB, Olsen MK, Butterfield MI, Calhoun PS. Is Military Sexual Trauma Associated with Trading Sex Among Women Veterans Seeking Outpatient Mental Health Care? Journal of Trauma and Dissociation 2011; 12(3):290-304.

Research Areas

Research Topics

  • Neurosteroids
  • Schizophrenia
  • Ptsd