Duke Institute for Brain Sciences

One important goal of neuroscience is to understand the fundamental principles that shape the developing brain. To achieve this goal, it is necessary to characterize the interactions between sensorimotor behavior and genetically programmed mechanisms of brain development. This interplay between intrinsic and experience-dependent factors is most dynamic during early life, at a time of explosive increase in the numbers and complexity of neural connections. It is precisely this increase in neural capacity that makes possible the rich repertoire of behavior associated with functional maturity. My primary interest is to understand how sensorimotor experience in early life influences—for better or worse—the formation and maturation of functional neural circuits in the cerebral cortex. My collaborators and I believe that our studies are providing insight into the nature of normal brain development and the consequences of disrupting the partnership between intrinsic developmental mechanisms and early sensorimotor experience.

Ph.D. Washington University in St. Louis, Neural Biology, 1992

M.B.S., Oral Roberts University, Physiology, 1987

B.S., Oral Roberts University, Biology, 1985

Kaschube M, Schnabel M, Löwel S, Coppola DM, White LE, Wolf F (2010) Universality in the evolution of orientation columns in the visual cortex. Science 330:1113-116. [see also “Perspectives” article by K.D. Miller published concurrently: Science 330:1059-1060.]

Experience with moving visual stimuli drives the early development of cortical direction selectivity. Li, Y,. Van Hooser, S.D., Mazurek, M., White, L.E. & Fitzpatrick D. (2008) Nature (22 Oct. 2008), doi: 10.1038/nature07417.

Extra-hippocampal involvement in HHV6 encephalitis depicted on MR imaging. Provenzale, J.M., vanLandingham, K., Mukundan, S. & White, L.E. (2008). Radiology(10 Oct. 2008) doi: 10.1148/radiol.2492071917.