James McNamara, M.D.

Photo of James McNamara

Phone: 919-684-0320

Physical Address:
101 I Bryan Res Bldg
Durham, NC 27710

Postal Address:
Box 3209 Med Ctr
Durham, NC 27710

Email: jmc AT neuro DOT duke DOT edu

Visit Member Website

Duke School of Medicine Professor of Neurosciences, Director, Center for Translational Neuroscience

Neurobiology, School of Medicine

DIBS Faculty, Member, DIBS Chairs & Directors Advisory Council

Research Description

Work in Dr. McNamara's laboratory seeks to elucidate the mechanisms of epileptogenesis, the process by which a normal brain becomes epileptic. Understanding the mechanisms of epileptogenesis in molecular terms may provide novel targets for pharmacologic interventions for prevention of epilepsy.


M.D., University of Michigan, 1968

A.B., Marquette University, 1964

Recent Publications

Roeloffs, R., Wickenden, A.D., Crean, C., Werness, S., McNaughton-Smith, G., Stables, J., McNamara, J.O., Ghodadra, N., and Rigdon, G.C. (2008). In vivo profile of ICA-27243, a potent and selective KCNQ2/Q3 activator in rodent anticonvulsant models. Journal of Pharmacology and Experimental Therapeutics, 326(3):818-828.

Danzer, S.C, Kotloski, R.J., Walter, C., Hughes, M. and McNamara, J.O. (2008). Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. Hippocampus, 18(7):668-678.

Huang, Y.Z., Pan, E., Xiong, Z.Q., and McNamara, J.O. (2008). Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber CA3 pyramid synapse. Neuron, 57:546-558.

Research Areas

Research Topics

  • Epileptogenesis
  • Signaling
  • Neurotrophins