333A Nanaline Duke Bldg.
Duke University Med. Center
Durham, NC 27710
Email: c DOT eroglu AT cellbio DOT duke DOT edu
Cell Biology, School of Medicine
Elucidation of cellular and molecular mechanisms that regulate the formation and experience-dependent plasticity of neural circuits presents an ultimate challenge in basic neuroscience research, as these processes are believed to underlie cognition, learning and memory. Such insight is also crucial to understand the pathophysiology of highly prevalent neurological disorders including mental retardation, autism, depression and addiction. In my lab our goal is to uncover the mechanisms that control synaptogenesis in the central nervous system (CNS), which is an important first step in the formation of circuits. Our perspective includes astrocytes as an integral part of the glutamatergic synapse and explores astrocytic contribution to the formation, plasticity and function of excitatory synapses in the CNS.
Postdoc, Stanford University, Neurobiology Department, Palo Alto CA, 2003-2008
Ph.D., European Molecular Biology Laboratory and University of Heidelberg (Germany), 2002
M.S., Bilkent University (Turkey), Molecular Biology and Genetics, 1998
B.S., Middle East Technical University (Turkey), Chemical Engineering, 1996
Astrocytes refine cortical connectivity at dendritic spines. Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz L-J, Singh JA, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH and Eroglu C (2014). eLife Dec 17, 17:3.
Huntingtin is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits. McKinstry SU, Karadeniz YB, Worthington AK, Hayrapetyan V, Ozlu MI, Molina-Serafin K, Risher WC, Ustunkaya T, Dragatsis I, Zeitlin S, Yin HH, Eroglu C (2014). J. Neuroscience, Jul 9;34(28):9455-72.
Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C. Proc Natl Acad Sci U S A. 2011. 108:E440-9.
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