366 Nanaline Duke Bldg.
307 Research Dr. Box 3709
Duke University Med. Center
Durham, NC 27710
Email: chay DOT kuo AT duke DOT edu
George W. Brumley Assistant Professor
Cell Biology; Neurobiology; Pediatrics, School of Medicine
DIBS Faculty, DIBS Investigator
We are interested in the regulation of postnatal/adult neural stem cells and how they modify brain homeostasis in health and disease. Throughout embryonic and postnatal development, neural stem cells give rise to differentiated neurons, astrocytes, and oligodendrocytes which modulate function of the adult nervous system. While during embryogenesis these progenitor cells are relatively abundant and help to construct the overall CNS architecture, during postnatal and adult periods they become restricted to specialized regions in the brain and produce progeny that participate in the modification of neural circuits and brain homeostasis. The work in my laboratory centers around understanding cellular pathways regulating postnatal/adult neural stem cells, using the rodent brain as a model system. Our current focus deals with how specialized environments in the brain (also called “niches”) sustain production of new neurons in vivo; how these microenvironments are changed in response to circuit-level inputs; and how injury modifies neural stem cell proliferation/differentiation. A better understanding of these processes may lead to future therapies for patients suffering from pre/postnatal brain injuries.
Postdoctoral Fellow, HHMI, UCSF, 2002-2007.
M.D., University of Chicago, 2002
Ph.D., University of Chicago, 1997
B.S., Massachusetts Institute of Technology, 1993
Benner, E.J., Luciano, D., Jo, R., Abdi, K., Paez-Gonzalez, P., Sheng, H., Warner, D.S., Liu, C., Eroglu, C., and Kuo, C.T. 2013. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature (497): 369-73.
Paez-Gonzalez, P., Abdi, K., Luciano, D., Liu, Y., Soriano-Navarro, M., Rawlins, E., Bennett, V., Garcia-Verdugo, J.M., and Kuo, C.T. 2011. Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. Neuron (71): 61-75.
Kuo, C.T., Mirzadeh, Z., Soriano, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N. 2006. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (127): 1253-1264.
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